Is being a night owl associated with higher migraine-related disability in patients with migraine?
Abstract
Introduction: Emerging evidence suggests that circadian rhythms may influence migraine pathophysiology through interactions between sleep-wake regulation and pain modulation pathways. This study aimed to investigate the association between chronotype and migraine-related disability in patients with migraine.
Methods: In this cross-sectional observational study, 200 patients with migraine and 110 healthy controls were included. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), chronotype was evaluated using the Morningness-Eveningness Questionnaire (MEQ), and migraine-related disability was measured using the Migraine Disability Assessment Scale (MIDAS). Episodic migraine (EM) and chronic migraine (CM) subgroups were also compared.
Results: Migraine patients exhibited poorer sleep quality (PSQI: 7.28 vs. 4.37, p p p = 0.48). Morning chronotypes had lower MIDAS scores (16.95 ± 16.17) compared to intermediate (23.93 ± 22.28) and evening types (23.55 ± 20.85), though differences were non-significant (p = 0.082).
Discussion: While chronotype does not directly correlate with migraine-related disability, poor sleep quality in migraine patients, particularly those with CM, underscores the need for sleep-focused interventions.
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 200 participants or records.
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