A preliminary study on brain functional magnetic resonance imaging in migraine patients with visual aura using visual stimulation
Abstract
Background and objective: Migraine is characterized by high prevalence, recurrent attacks, and poor response to pharmacological interventions, which can severely impair patients' quality of life. The complex and diverse aura symptoms in its clinical presentation further increase the risk of misdiagnosis and mismanagement. Moreover, the pathogenesis of this disorder remains incompletely understood. This study employed a visual stimulation paradigm combined with blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) to simultaneously monitor brain functional activity and neuronal dynamics in patients with visual aura migraine (VaM) and migraine without aura (MwoA). The aim was to identify specific brain network features associated with visual aura in VaM, thereby providing new insights into its pathological mechanisms and early differential diagnosis.
Methods: From May 2023 to May 2024, 21 patients meeting the diagnostic criteria for VaM and excluding related ocular fundus and optic nerve pathologies during the interictal period (VaM group), 21 patients meeting the criteria for MwoA during the interictal period (MwoA group), and 21 gender- and age-matched healthy controls (HC group) were recruited from the Department of Neurology, Affiliated Hospital of North Sichuan Medical College. All participants underwent visual stimulation using an 8 Hz flickering checkerboard paradigm concurrent with task-state fMRI scanning and image acquisition. The…
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