Abstract DP238: Migraine and Intracerebral Hemorrhage Outcomes: A National Inpatient Analysis
Abstract
Introduction:
Migraine is a neurovascular disorder associated with cerebrovascular events, yet its effect on intracerebral hemorrhage outcomes remains unclear. Shared pathophysiological mechanisms, could influence outcomes following intracerebral hemorrhage.
Methods:
This retrospective cohort study used the National Inpatient Sample (NIS) database (2016–2021) to identify non-traumatic intracerebral hemorrhage hospitalizations with and without migraine. The primary outcome was in-hospital mortality, and secondary outcomes included length of stay, favorable discharge, and intracerebral hemorrhage-related complications (e.g., shunt placement and pneumonia). Propensity score matching (1:1) was performed and outcomes were analyzed using survey-weighted logistic regression. Sensitivity analyses were conducted for migraine subtypes and intracerebral hemorrhage location.
Results:
Of 76,775 intracerebral hemorrhage hospitalizations (national weighted estimate: 383,874), 1,376 (weighted: 6,880) had a secondary migraine diagnosis, representing a 1.8% of the sample. Cohort showed a mean age of 67.6 (SD 15.1) and slight male predominance (52.7%). After successfully matching 2,694 intracerebral hemorrhage hospitalizations in a 1:1 ratio, those with migraine had lower in-hospital mortality (10.0% vs. 16.5%, OR=0.56 [95%CI=0.43–0.72]), higher favorable discharge rates (36.7% vs. 28.1%, OR=1.48 [95%CI=1.24-1.78]), and lower pneumonia prevalence (3.6% vs. 5.8%, OR=0.61 [95%CI=0.41–0.91]).…
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