Nebulized Gentamicin for Reducing Colonization of Tracheostomy Tubes: From Neuro ICU to Community: A Double-blind Randomized Controlled Trial
Abstract
Background Tracheostomy tube colonization rates are high ranging from 30-100% within 48 hours of tracheostomy tube. Tracheostomy tube colonisations and resultant infections such as ventilator associated pneumonia have a significant impact on patient health, medical resources, quality of life. The aim of the study is to determine the efficacy of prophylactic gentamicin nebulization for tracheostomy tube colonization in neurocritical care patients in ICU and after step down into ward and community. Primary objective To compare the rate and change of pathogenic colonization of tracheostomy tubes between two groups over the course of treatment. Secondary objective To compare the incidence of VAI/LRTI, stoma granulation, tracheostomy tube block, and adverse events related to nebulization between the two groups in hospital and on follow-up. To study the risk factors associated with colonization. Methods We conducted a double blind randomized controlled trial to compare the incidence of pathogenic colonization of tracheostomy tubes between the gentamicin nebulization and saline nebulization groups at 3 time points: 7-10 days after tracheostomy (TT change 1), and at death/discharge/2-3 weeks from last tracheostomy tube change (TT change 2) and day 60 of tracheostomy/one month after discharge /decannulation (TT change 3) which may be in the hospital or community) whichever is earlier. 65 patients were randomized into either twice daily nebulized gentamicin 80 mg (2ml) which is…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 65 participants or records.
Read the paper
Related studies
- Penicillins for Treatment of Pneumococcal Pneumonia: Does In Vitro Resistance Really Matter?
- Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors
- Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy
- Development and validation of microbial bioassay for quantification of Levofloxacin in pharmaceutical preparations
- GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
- Propranolol, chlorpromazine and diclofenac restore susceptibility of extensively drug-resistant (XDR)-Acinetobacter baumannii to fluoroquinolones
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.