Peripherally acting anti-CGRP monoclonal antibodies alter cortical gray matter thickness in migraine patients: A prospective cohort study
Abstract
Highlights • Anti-CGRP-mAbs change cortical thickness after 3-month treatment.• Decreased thickness was observed in specific cortical regions in the responders.• Results could reflect recovery process from the hyperexcitable brain state in migraine.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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