Associations between migraine attacks and nightly sleep characteristics among adults with episodic migraine: a prospective cohort study
Abstract
STUDY OBJECTIVES
Given the unknown immediate impact of migraine on nighttime sleep, we prospectively examined whether migraine headaches were associated with subsequent shorter sleep duration, higher fragmentation and poorer quality in a cohort of 98 adults with episodic migraine.
METHODS
Participants completed twice-daily electronic diaries and wore actigraphs continuously for 6 weeks. We examined whether days with headaches were associated with changes in that night's sleep characteristics compared to non-headache days, using adjusted multivariable linear mixed models with subject-specific intercepts.
RESULTS
Participants were 35 ± 12 years old, 88% women, with an average of five migraine headaches/month. Over 4406 days, we observed 1077 headache days, representing 823 discrete headaches. Average nightly objective sleep duration was 7.3 ± 1.2 hours, efficiency 89.5 ± 3.3% and wake after sleep onset (WASO) 44.8 ± 17.0 minutes. Objective sleep duration was 7.3 minutes (95% CI:1.5, 13.0) longer on nights following a headache day compared to nights on a headache-free day. Objective sleep efficiency, WASO, and reported sleep quality were not significantly different on headache days compared to headache-free days (sleep efficiency: -0.06 min.
CONCLUSIONS
Sleep periods immediately following migraine headaches are not associated with shorter sleep duration, higher sleep disruption, or poorer sleep quality in patients with episodic migraine. These results suggest that clinical…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 98 participants or records.
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