Relationship between white matter hyperintensity and atherogenic index of plasma in migraine
Abstract
OBJECTIVE: White matter hyperintensities (WMH) are more commonly observed in patients with migraine compared to the general population; however, their pathophysiology remains incompletely understood. This study aims to investigate the relationship between the atherogenic index of plasma (AIP), a vascular risk marker, and WMH in patients with migraine.
METHODS: This study included 274 patients diagnosed with migraine according to the International Classification of Headache Disorders (ICHD-III). The relationship between WMH and AIP in migraine patients was validated by Two-State Logistic Regression Analysis, and the cubic spline curve was used to determine linearity.
RESULTS: The mean age of the patients with migraine was 36.26 ± 8.37 years and 82.8% (n = 227) were female. The the prevalence of aura (p = 0.028), age (p = 0.001) and mean disease duration (p < 0.001, t=-4.257) were significantly higher in migraine patients with WMH than those without WMH. AIP (p < 0.001, t=-6.667), triglyceride (TG) (p < 0.001, t=-5.736) and body mass index (BMI) (p = 0.020, t=-2.344) were significantly higher in patients with WMH compared to those without WMH. A two-state regression analysis demonstrated a linear relationship between increased AIP (OR:7.101, 95% CI:3.417-14.174), TG (OR: 1.016, 95% CI: 1.005-2.023) and WHM in patients with migraine.
CONCLUSION: In our study, we found positive correlation between WMH and AIP values in patients with migraine, and showed that AIP values were a…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 274 participants or records.
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