Association between TNFa rs1800629 and migraine: Case-control study and updated meta-analysis
Abstract
Migraine is a multifactorial disorder influenced by both genetic and environmental factors. In this study, we aimed to explore the association of tumor necrosis factor alpha (TNFa) rs1800629 with migraine susceptibility. A case-control study design was employed to assess this association in individuals of Greek ancestry. Subsequently, a meta-analysis of published studies was conducted, thereby incorporating the findings of the present study to further evaluate the relationship between rs1800629 and a migraine. A total of 123 patients with migraines (44.4 ± 10.3 years, 105 women) and an even number of healthy controls (HC) (58.7 ± 12.0 years, 76 women) were recruited. TNFa rs1800629 was in Hardy–Weinberg equilibrium among the HC (P = 1.00). No association was observed between TNFa rs1800629 and migraines under any genetic model. Additional, subgroup analyses stratified by sex and migraine subtype showed no associations. The meta-analysis, comprised of 14,742 participants with migraines and 46,384 HC, indicated a trend towards a risk-conferring effect of rs1800629 [Odds ratio (OR) = 1.26, 95% confidence interval (95% CI) = (0.97–1.64), P = 0.09]. Subgroup analyses revealed a significant association in individuals of Asian ancestry [OR = 1.64, 95% CI = (1.08–2.48), P = 0.02]. Additionally, the over-dominant model was related to migraines with aura [OR = 1.21, 95% CI = (1.08–1.35), P = 0.001]. Subgroup analyses for men and women, as well as for migraines without aura, were…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 14,742 participants or records.
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