Analysis of the DNA methylation pattern of the promoter region of calcitonin gene-related peptide 1 gene in patients with episodic migraine: An exploratory case-control study
Abstract
Highlights • Patients with episodic migraine showed a different methylation pattern in 2 CpG sites at the proximal promoter region of CALCA gene, that encodes the calcitonin gene-related peptide (CGRP).• Intriguingly, one of the two hypomethylated site (-1415) is located at the CREB binding site.• DNA methylation level at different CpG sites in CALCA promoter correlates with several clinical characteristics of migraine.• Our study provides evidence that the methylation of CALCA gene is reduced in patients with migraine and this hypomethylation could play a role in the disease.
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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