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Case series of SMART syndrome in a tertiary hospital in Gran Canaria

Relloso de la Fuente A, García Granado JF, Quesada Morales OG, Pérez Vieitez MDC, Alemany Rodríguez MJ, González Hernández AN

Revista clinica espanola, 2026

1 citation

Abstract

INTRODUCTION

SMART (stroke-like migraine attacks after radiation therapy) syndrome is a possible complication of radiotherapy used in the treatment of brain tumours. The current prevalence is not well known, partly because it is underdiagnosed.

MATERIAL AND METHODS

A descriptive, prospective study was designed over a period of 18 months. Demographic, clinical, analytical and neuroimaging variables were collected.

RESULTS

Three patients were included who, after receiving holocranial radiotherapy, developed focal neurological symptoms after a variable latency period. After ruling out other possible aetiologies, the diagnosis of SMART syndrome was established.

CONCLUSION

This case series aims to raise awareness among professionals of the importance of training in this pathology, especially in view of the advances in oncological treatments and the expected increase in its incidence.

How strong is the evidence?

Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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