Understanding Neuro-modulatory mechanism of Nasya karma with Dashamoola Ghrita in Migraine with CGRP biomarker- A case series
Abstract
Introduction: This case series explores the effect of Dashmoola Ghrita Marsha Nasya on migraine in relation to CGRP, a key neuromodulator in migraine pathophysiology. While CGRP has been extensively studied in modern medicine, its modulation through traditional Ayurvedic therapies remains underexplored. Clinical Findings: Three patients with episodic migraine presented with moderate to severe headaches, photophobia, and nausea. All had elevated MIDAS scores and serum CGRP levels, indicating significant disability and active neuroinflammatory response. Intervention: Patients underwent Marsha Nasya with Dashmoola Ghrita (8 bindu) for seven consecutive days. Outcomes: Post-treatment, patients demonstrated an average 34% reduction in MIDAS scores and an average 40% decrease in serum CGRP levels, indicating both symptomatic relief and biochemical parameters. Conclusion: Dashmoola Ghrita Marsha Nasya may exert a neuro-modulatory effect on CGRP and improve clinical outcomes in migraine. These findings suggest the potential role of integrating Nasya therapy with biomarker-based evaluation in the management of migraine.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.