Delayed Diagnosis of Primary Sjögren's Syndrome presenting as Atypical Migraine - A Case Report
Abstract
Introduction: Primary Sjögren's Syndrome usually presents with Sicca symptoms but may initially manifest with non-specific neurological complaints such as migraine, paresthesia or dizziness.
History: A 34-year-old woman reported recurrent headaches, dizziness, and a single episode of mild aphasia; she was initially diagnosed with migraine without aura. Despite stage-appropriate therapy, additional symptoms such as dry mouth and eyes as well as arthralgia developed.
Findings and diagnostics: Cranial imaging was unremarkable. Orbital Doppler sonography revealed widened optic nerve sheaths. Autoimmune serology was positive for ANA, ENA, and Anti-SSA antibodies. Schirmer test, tear film break-up time, and salivary flow confirmed sicca syndrome.
Therapy and course: After diagnosis, treatment with prednisolone and hydroxychloroquine was initiated, leading to a significant improvement in neurological and extraglandular symptoms. Pilocarpine along with supportive eye and oral care improved the sicca symptoms.
Conclusion: Non-specific neurological symptoms may represent early in Primary Sjögren's Syndrome, highlighting the importance of early serological testing and interdisciplinary evaluation.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.