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Kleine-Levin Syndrome Accompanied With Complex Headache:Report of One Case

Zhang L, Li ZB, Liu H, Wang XL, Liu RZ

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2026

Abstract

Kleine-Levin syndrome is an extremely rare sleep disorder.In addition to recurrent daytime sleepiness,symptoms such as overeating,hypersexuality,cognitive impairment,and mental and behavioral abnormalities usually occur.Hypothalamic dysfunction may be the underlying pathogenesis.Cases with headache are rare.We reported a case of Kleine-Levin syndrome with headache symptoms during narcolepsy,and his headache was characterized by both migraine and cluster headache.It is hypothesized that Kleine-Levin syndrome may have a potential common pathogenesis with functional headaches such as migraine or cluster headache,which may be related to hypothalamic dysfunction.

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