Tolosa-Hunt Syndrome With Highly Elevated Interleukin-6 Levels
Abstract
Tolosa-Hunt syndrome is a rare disorder of idiopathic granulomatous orbital inflammation associated with ipsilateral orbital pain and cranial nerve palsy. The patient is a 42-year-old Hispanic female with Ecuadorian ancestry who presented in remission of episodes of horizontal diplopia, left eye proptosis, and 8/10 sharp left eye pain that occurred 10 years ago and four years ago. Both episodes resolved with about five weeks of oral methylprednisolone dosing prescribed at onset of symptoms. She is successfully maintained on oral methylprednisolone six-day dose pack about twice yearly for moderate orbital pain. At the time of the diplopia four years ago, Magnetic Resonance Imaging showed a left cavernous sinus mass, which resolved on subsequent imaging. Her interleukin 6 (IL-6) serum level done during remission and during clinical episodes was highly elevated at 90.5 pg/ml (normal <5 pg/ml) and 68.7 pg/mL, respectively. Lower level during clinical episode may be due to use of oral steroid medication. The cytokine elevation may provide clues regarding the pathophysiology of this unusual neurological disorder.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.