Efficacy and safety of post-mastectomy radiation therapy for patients with breast cancer after breast reconstruction: A retrospective multicenter cohort study (Reborn-03)
Abstract
579
Background:
A cornerstone of multidisciplinary treatment for breast cancer, breast reconstruction has recently been extended to high-risk patients with breast cancer who require post-mastectomy radiation therapy (PMRT). PMRT reduces the 10-year risk of locoregional recurrence; however, its association with postoperative complications remains unclear. This study aimed to evaluate the efficacy and safety of PMRT in patients with high-risk breast cancer who underwent breast reconstruction.
Methods:
This retrospective cohort study included patients with high-risk breast cancer who underwent immediate or delayed breast reconstruction after mastectomy between 2008 and 2018. High-risk patients were defined as those with positive axillary lymph nodes, clinical tumor size of >5 cm, chest wall invasion, or skin invasion. Patient data were collected from participating institutions and analyzed retrospectively.
Results:
Of the 1,138 patients, 427 (37.5%) underwent PMRT and 711 (62.5%) did not. The median age at surgery was 46 years (range, 23–76years), and the median follow-up period was 8 years. The number of patients meeting more than two high-risk criteria was 149 (23.9%) and 81 (11.4%) in the PMRT and non-PMRT cohorts, respectively. Breast reconstruction using silicone breast implants (SBI) was performed in 70% and 71.4% of patients in the PMRT and non-PMRT cohorts, respectively. The locoregional recurrence rates were 7.7% and 12.7% in the PMRT and non-PMRT cohorts, respectively…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 1,138 participants or records.
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