P-1488. Clinical Efficacy of Minocycline in the Treatment of Carbapenem-resistant Acinetobacter baumannii Pneumonia
Abstract
Abstract Background Minocycline is one of the few antibiotics that remain active against carbapenem-resistant Acinetobacter baumannii (CRAB). However, the efficacy of minocycline in CRAB pneumonia has not been clearly demonstrated. Methods We conducted a multicenter retrospective cohort study at three university-affiliated teaching hospitals in patients with CRAB pneumonia who were admitted between October 2017 and October 2022. Patients were divided into two groups depending on whether minocycline was included in the antibiotics treatment regimen. Propensity scores for minocycline use were calculated using logistic regression, and logistic regression with overlap weighting was conducted to assess whether there were significant differences in outcome variables and safety variables between the two groups. Results We enrolled 430 CRAB pneumonia patients, among which 201 patients were treated with minocycline and 229 patients without minocycline. Intensive care unit stay was more frequent (77.6% vs 65.1%, P value = 0.006) and serum creatinine was higher (0.9 vs 0.8 mg/dL, P = 0.023) in the minocycline group than in the non-minocycline group. Variables associated with minocycline use in logistic regression were cerebrovascular disease (odds ratio [OR] 4.51, 95% confidence interval [CI] 2.07–9.85, P < 0.001), higher serum creatinine (OR 1.37, 95% CI 1.01–1.87, P = 0.046), and combination antibiotic regimen (OR 124.73, 95% CI 43.23–359.84, P < 0.001). Bacteremia (OR 0.19, 95% CI…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 430 participants or records.
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