Patients’ Values and Preferences Regarding the Pharmacologic Treatment of Acute Episodic Migraine
Abstract
BACKGROUND
Understanding patients' values and preferences is essential for guideline development.
PURPOSE
To identify and synthesize evidence on patients' values and preferences for the American College of Physicians (ACP) clinical guideline on the pharmacologic treatment of acute attacks of episodic migraine.
DATA SOURCES
MEDLINE (Ovid) and CINAHL (EBSCO) were searched from inception to October 2024, and backward citation searches on pertinent publications were performed.
STUDY SELECTION
Reviewers dually screened abstracts and articles.
DATA EXTRACTION
One reviewer performed data extraction, and a second team member checked for accuracy. Risk of bias was assessed in the included studies dually.
DATA SYNTHESIS
The data were synthesized narratively and the certainty of evidence (COE) was assessed using GRADE (Grading of Recommendations Assessment, Development and Evaluation) and GRADE-CERQual (GRADE-Confidence in the Evidence from Reviews of Qualitative Research) guidance. Of 2243 references screened, we included 16 quantitative studies and 1 qualitative study. Effectiveness for pain was rated as more important than avoiding harms (moderate COE) or treating accompanying symptoms (moderate COE). Both effectiveness for pain and avoiding harms were more important than other attributes such as convenience or route of administration (moderate COE). Relieving nausea and vomiting was more important than other accompanying symptoms, such as photophobia (moderate COE). Cost was not…
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