Effect of short-term air pollution exposure on migraine: A protocol for systematic review and meta-analysis on human observational studies
Abstract
BACKGROUND
The World Health Organization (WHO) has identified air pollution as one of the greatest environmental risks to public health. High levels of ambient air pollution are known to have adverse health effects, but the relationship between exposure to air pollutants and migraine attack has not been established.
OBJECTIVES
This study aims to systematically review the effects of short-term exposure to fine and coarse particulate matter (PM), ozone, nitrogen dioxide, sulfur dioxide, and carbon monoxide on migraine attack.
METHODS
The systematic review and meta-analysis will follow the WHO handbook for guideline development. Our protocol will comply with the guidelines of the Preferred Reporting Items for Systematic Review and meta-Analysis Protocols.
ELIGIBILITY CRITERIA
Original peer-reviewed studies conducted in the general population regardless of age and sex to investigate the association between short-term exposure to ambient air pollutants and migraine will be eligible for inclusion. Only time-series, case-crossover, and panel studies will be included.
INFORMATION SOURCES
We will search the electronic databases MEDLINE, Embase, Web of Science, Global Health, Cumulative Index to Nursing and Allied Health Literature in accordance with the pre-established search strategy. We will also check the reference list of included papers and previous reviews for supplementary search.
DATA SYNTHESIS METHOD
We will perform data extraction in accordance with the predesigned table.…
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Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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