The association between parental migraine, infantile colic, and later migraine in childhood: A scoping review of current evidence
Abstract
Background: Evidence suggests that infantile colic, a common condition in early infancy, shares pathophysiological features with migraine.
Objective: Aim was to examine the current evidence on the association between infantile colic and migraine, focusing on both maternal migraine as a risk factor for infantile colic and infantile colic as a predictor of later childhood migraine.
Design: We performed a scoping review.
Methods: We performed a scoping review and searched the PubMed, Scopus, and Web of Science databases from inception to 30 September 2025. Observational studies examining either maternal migraine and infantile colic or infantile colic and subsequent childhood migraine were included. Data were extracted on study design, population characteristics, and effect estimates. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were extracted where available, and crude ORs were calculated when necessary.
Results: Twelve observational studies published from 1997 through 2025 were included. Estimates varied widely across six studies focusing on maternal migraine and infant colic, with ORs ranging from 0.97 to 37.71, reflecting substantial heterogeneity in study design, populations, and definitions. Another six studies showed that infantile colic was associated with later migraine, with ORs ranging from 0.50 to 107.14, although estimates varied substantially and some CIs were wide.
Conclusion: Available observational evidence suggests a consistent association…
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.