Migraine relief: Solutions from natural bioactive products of Traditional Chinese medicine
Abstract
Ethnopharmacological relevance: Migraine is a chronic and refractory primary neurological disorder that is characterized by recurrent and pulsating headache accompanied by reversible neurological or systemic symptoms, such as visual aura, phonophobia, and gastrointestinal symptoms. Natural bioactive products derived from traditional Chinese medicine (TCM) are regarded as promising candidates for migraine owing to multi-target and pathway synergistic effects.
Aim of the study: This paper aims to systematically evaluate the therapeutic effects of natural bioactive products from TCM on migraine, elucidate the roles of neurons, microglia, and astrocytes in the pathogenesis of migraine, and propose novel therapies for migraine from TCM.
Materials and methods: The publications were summarized from 2015 to 2025 in the Google Scholar, PubMed, and Web of Science databases. The keywords used for the search were "migraine", "neurons", "microglia", "astrocytes", "natural products", and "TCM". The bibliometrics was used to analyze the research hotspots of literature on TCM and migraine over the past decade. The Global Burden of Disease Study (2023) and network pharmacology analysis were conducted on migraine.
Results: The abnormal communication between neurons and glial cells contributes to the pathological process of migraine, manifested as cortical spreading depression, neuroinflammation, and central sensitization. Correcting the vicious cycle of headache attacks to restore the…
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