Association between maternal migraine and infantile colic: a narrative review
Abstract
Background: Infantile colic (IC) is a common and distressing condition characterized by excessive crying and fussiness in otherwise healthy infants, typically resolving by three to four months of age. The etiology of IC remains poorly understood, but shared mechanisms with maternal migraine, such as genetic predisposition, sensory hypersensitivity, and gastrointestinal dysregulation, suggest a potential association. This narrative review aims to explore the relationship between maternal migraine and IC, summarizing current evidence and potential underlying mechanisms.
Methods: A comprehensive search was conducted in electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar, from 2010 up to August 22, 2024. Studies were included if they investigated the association between maternal migraine and IC, included human participants, and were published in English. Case-control and cross-sectional studies providing original data were narratively analyzed. Data extraction focused on study characteristics, maternal migraine and IC definitions, and key findings.
Results: Out of 792 screened studies, 8 met the inclusion criteria, including 5 case-control and 3 cross-sectional studies. Most studies demonstrated a significant association between maternal migraine and IC, with maternal migraine increasing the likelihood of IC by 2.6 to 5 times. Proposed mechanisms include dysregulation of the trigeminovascular system, sensory hypersensitivity, disrupted sleep-wake…
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.