Altered Brain Structure and Function Correlate with Disease Severity and Pain Catastrophizing in Migraine Patients
Abstract
Our study provides a new and comprehensive look at how migraine affects brain structure, how these changes in structure are related to functional brain networks, and how coping and disease severity influence both structure and functional networks. Specifically, we demonstrate concomitant functional and structural brain changes related to pain catastrophizing and disease severity in migraine patients. Abstract Cover Figure Migraine patients (Pts) show widespread structural and functional brain changes that are associated with symptoms and increased pain catastrophizing A, Migraine patients showed (i) increased gray matter volume (GMV) in the left (L) hippocampus and (ii) decreased cortical thickness in the L anterior midcingulate cortex (aMCC) compared to healthy control subjects. B, Pain catastrophizing correlated with GMV reductions in the (i) L primary somatosensory cortex (S1) and (ii) L medial prefrontal cortex (mPFC), and cortical thinning in the (iii) L dorsolateral prefrontal cortex (DLPFC) and middle temporal gyrus (MTG) in migraine patients. C, GMV reductions correlated with (i) disease duration (ii), attack frequency, and (iii) migraine pain intensity in patients. D, Whole-brain overlay maps for migraine patients and healthy controls for the (i) L PCC, (ii) L aINS, and (iii) aMCC seed regions rendered onto inflated brains. Red represents resting-state functional connectivity for healthy controls and green represents the same maps in migraine patients. Yellow…
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