Effect of serotonin in migraine patients
Abstract
EFFECT OF SEROTONIN IN MIGRAINE PATIENTS Robert W. Kimball, Arnold P. Friedman, and Edward Vallejo Neurology 1960;10:107–111 Little is known of the factors that predispose to migraine or the biochemical events that initiate the disturbances characteristic of this condition. Earlier studies by Marcussen and Wolff have shown that an initial phase of vasoconstriction is responsible for the prodromal symptoms, while the pain follows a marked distention of cranial vessels that are temporarily hypotonic. They also have presented certain evidence which presumably indicates that a pain threshold-lowering substance renders the distention of the large arteries painful. However, alteration in tone, lumen, and pain threshold of the arteries alone cannot explain the complex symptomatology of the migraine attack.
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