A Comparison of Migraine Patients With and Without Allodynic Symptoms
Abstract
BACKGROUND: Although the association of symptoms of allodynia with migraine have been reported, there is a paucity of studies on Asians. AIMS: To evaluate allodynic symptoms in migraine patients and its relationship with various clinical variables. METHODS: Consecutive migraine patients meeting the International Headache Society criteria were evaluated. Frequency, duration of illness, precipitating factors and severity of headache, associated symptoms, and functional disability were noted. Presence of allodynic symptoms and its distribution were recorded and correlated with demographic and clinical variables. RESULTS: One hundred eighty-two consecutive patients with migraine without aura were included. Mean age was 30.7 years and 51 of the patients were males. Allodynic symptoms were present in 57.1%, which were triggered by various stimuli. In majority of patients, allodynic symptoms were induced by multiple stimuli. Symptoms of allodynia were restricted to the initial site of headache in 32.7%, holocranial in 46.2% and cephalic and extracephalic in 21.1% patients. Duration, frequency of migraine attacks, and functional disability were significantly associated with allodynic symptoms. Rizatriptan resulted in better relief of headache at 2 hours compared with ibuprofen in allodynic patients. CONCLUSIONS: Allodynic symptoms occurred in 57.1% patients with migraine. In allodynic patients with moderate-to-severe headache, rizatriptan resulted in greater pain relief compared…
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.