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The Effect of Treatment Onset Time on Acute Treatment Efficacy in Migraine Patients Using Remote Electrical Neuromodulation (REN)

ClinicalTrials.gov · COMPLETED, 2025

55,261 participants

Abstract

This is a Post-marketing study investigating the impact of treatment time onset with Nerivio on the efficacy of Remote Electrical Neuromodulation (REN) for the acute treatment of migraine.

Efficacy will be evaluated as a change in headache pain severity and functional disability from baseline to 2 hours post-treatment in at least 50% of the treatments, based on the treatment start time from the beginning of the migraine attack.

Conditions: Migraine, Acute Treatment of Migraine.

Primary outcome: Pain Relief; Pain Freedom:.

Enrollment: 55261 participants.

How strong is the evidence?

Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 55,261 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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