Investigating Heritable Stroke Genes in Migraine and Migraine Related Disorders
Abstract
This research investigated the genetic relationship between migraine and stroke-related small vessel disease using whole exome sequencing, family-based analysis, and case-control association studies. Several rare variants were identified in genes involved in vascular integrity, endothelial function, and neuronal signalling, including CTC1, LRP1, NOTCH3, COL4A2, and ACE. A significant association was identified between a CTC1 variant and migraine susceptibility, supporting shared neurovascular mechanisms underlying migraine and cerebrovascular disease. These findings expand current understanding of migraine genetics and provide a foundation for future precision diagnostics and targeted therapeutic strategies.
How strong is the evidence?
Evidence Hub reads this as a case-control. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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