Prevalence and Antibiotic Susceptibility Pattern of Multidrug-Resistant Pseudomonas aeruginosa in a Tertiary Hospital, South Sumatera, Indonesia
Abstract
ABSTRACTBackground: Pseudomonas aeruginosa is a Gram-negative bacterium that causes opportunistic and healthcare-acquired infections. Its ability to rapidly acquire antibiotic resistance complicates treatment, prolongs hospitalization, and increases morbidity, mortality, and healthcare costs. Objective: This study aimed to determine the prevalence and antibiotic susceptibility pattern of multidrug-resistant P. aeruginosa at Dr. Mohammad Hoesin General Hospital, South Sumatera, Indonesia.Methods: A descriptive observational study with a cross-sectional design was conducted using data from the Clinical Microbiology Laboratory and Medical Records Installation of Dr. Mohammad Hoesin General Hospital, Palembang, from May 2022 to April 2023. Data were analyzed univariately and presented through tables, figures, and descriptive summaries.Results: A total of 465 hospitalized patients were found to be infected with P. aeruginosa. Adult patients aged 18–65 years were the most affected (71%). The leading primary diagnoses were diabetic foot ulcer, pneumonia, and sepsis. Most patients were hospitalized for 8–14 days (25.2%). Antibiotic susceptibility testing showed the highest sensitivity to amikacin (94.2%), while the lowest was observed with meropenem and ceftazidime. The resistance profile included 24.7% MDR, 6.7% XDR, 0.9% probable PDR, and 2.4% DTR isolates.Conclusion: P. aeruginosa infections were predominantly found in adult patients with prolonged hospitalization. Amikacin…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 465 participants or records.
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