Peripheral and central sensitization during migraine
Abstract
Current theories propose that the pain of migraine is caused by chemical activation of meningeal perivascular fibers. In an animal model of migraine, we have recently shown that chemical activation of meningeal primary afferent nociceptors that innervate the dura could lead to the following: a) peripheral sensitization of these nociceptors to intracranial mechanical stimulation; b) central sensitization of second-order trigeminovascular neurons that receive convergent input from the dura and skin to extracranial mechanical and thermal stimulation; and c) facilitated cardiovascular pressor responses that are usually indicative of pain. These findings provide the first set of evidence for the induction of peripheral and central sensitization along trigeminovascular pain pathways by visceral input from the intracranial dura. We propose that the throbbing pain of migraine is mediated mainly through peripheral and to a lesser extent through central sensitization, and that the development of scalp tenderness is mediated mainly through central sensitization.
How strong is the evidence?
Evidence Hub reads this as a review, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.