Increased metabolite concentration in migraine rat model by proton MR spectroscopy in vivo and ex vivo
Abstract
PURPOSE: To investigate brain metabolite change in rat migraine model by proton magnetic resonance spectroscopy (1H-MRS) in vivo and ex vivo.
METHODS: 18 Adult SD rats were enrolled in the study. After nitroglycerin administration, the migraine rat model was established according to ethology evaluation. 1H-MRS was performed at 3T MR scanner in vivo and 14.7T Bruker MR spectrometer ex vivo. Area of peak for different metabolite material was obtained and compared by using independent-T test. The significance level was set at p<0.05.
RESULTS: In thalami of experimental group, areas of peak for Cho, Cr and Glu both in vivo and ex vivo were higher than in control group(p<0.05). In contrast, there was no statistical difference in cerebellum.
CONCLUSION: The elevated Cho and Cr spectral pattern were found in rat migraine model. Neuron activity in thalamus is significantly changeable during attacks.
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