Establishment Evaluation and Proof of a Novel Migraine Animal Model Representing Wind-Heat Syndrome
Abstract
Objective:To try to establish a novel migraine animal model representing wind-heat syndrome.Method:Establishing rat model by having animals blew hot wind and GTN administration,taking pictures of rats' tongues,auricles and conjunctivae,analyzing the gray scale of rat tongues to evaluate the TCM syndrome and demonstrating the syndrome by Xiong Zhi Di Long Tang.Result:The gray scale level of tongue in GTN groups were significantly higher than control group(P0.01);the gray scale level in medicated group was slightly lower than GTN groups(P0.05).Observed by naked eyes,auricles and conjunctivae showed more blood vessel network than the control group.Wind-heat did not cause any significant difference between groups.Conclusion:GTN administration can cause changes in the manifestation of rat tongues,auricles and conjunctivae.The wind-heat syndrome model needs to be further considered to grow mature.
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