Study on the migraine animal model induced by chemical stimulation on the superior sagittal sinus in RAT
Abstract
Objective: To investigate the feasibility of the migraine animal model induced by chemical stimulation on the superior sagittal sinus.Method: The rats were prepared by exposure to the superior sagittal sinus.The dura mater near the SSS was stimulated by capsaicin and c-fos(Fos) protein was detected in periagueductal grey matter(PAG) area in coronal brain sections by using standard avidinbiotin immunohistochemistry.Result: The numbers of Fos immunoreactive positive neurons in capsaicin 1 μM group and 10 μM group was 116.7±13.5 and 304.2±18.9 respectively.While in control group and vehicle group was 35.2±9.4 and 44.1±11 respectively.Conclusion: The PAG could be activated by the capsaicin chemical stimulation of the dura mater near the SSS.The migraine animal model by using chemical stimulation of capsaicin evoked the general process of migrain attacks.
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