Histopathological effects of repeated 14-day administration of rizatriptan benzoate in a nitroglycerin-induced migraine rabbits model
Abstract
Background: Migraine is one of multiple attack neurological conditions that causes moderate to severe headaches with no defined pathophysiology and few animal models. Aim: Establishing an animal model that reproduces migraine-like action is important in medical research to identify the mechanism underlying this disorder. Additionally, it facilitates the availability and reliability of new models that may act as human surrogate models. Method: Rabbits were divided into four groups. Negative group, migraine group, rizatriptan-nitroglycerin group, and rizatriptan group. The frequency of head scratching and the histopathological changes in the brain, liver, kidney, and heart for groups were evaluated in all groups. Results: The behavioral characteristic of head scratching was significantly increased in the NTG group (50.4 ± 3.8) compared with the control group (9.2 ± 1.3) after 30 min of the experiment. Moreover, animals treated with rizatriptan benzoate (Riza) 10 mg/kg/orally for 14 days followed by NTG injection showed a significant decrease in the head scratch action (16.8 ± 2.3 and 17.6 ± 3.3) than the animals of NTG group (50.4 ± 3.8 and 43.6 ± 2.3) after 30 min and 60 min, respectively. Furthermore, animals treated with Riza alone showed no statistical differences in the head scratches (7.8 ± 1.3, 9.2 ± 0.8, 10.6 ± 1.1 and 9.6 ± 1.3, respectively) during the 120 min of the experiment, compared with the control group. Histopathological alterations in the brain of…
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