EHMTI-0141. URB937 as a potential therapeutic option for migraine: evaluation in animal model of migraine
Abstract
Systemic nitroglycerin (NTG) activates cerebral nuclei of rat involved in nociceptive transmission, as well as in neuroendocrine and autonomic functions. These changes are considered relevant for migraine pain, since NTG consistently provokes spontaneous-like migraine attacks in migraineurs. Several reports have suggested the existence of relations between the endocannabinoids and migraine. URB937, a peripheral fatty acid amide hydrolase (FAAH) inhibitor, induces analgesia in animal models of pain but there is no information on its effects in migraine.
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