Effects of URB937 on an animal model of migraine pain
Abstract
Several studies have suggested the existence of interactions between the endocannabinoids and migraine. URB937, a FAAH inhibitor specific to peripheral tissues, causes analgesia in animal models of pain [1]. In this study, we evaluated whether the URB937 administration may alter nociceptive responses in an animal model of migraine based on nitroglycerin (NTG)-induced hyperalgesia [2]. Rats received systemic NTG and URB937 before being evaluated at the Tail flick test or at the Formalin test. The findings show that URB937 did inhibit NTG-induced hyperalgesia at the Formalin test with only a minimal influence on the hyperalgesia at the Tail flick. The data suggest that availability of anandamide probably at the meningeal level is effective in the migraine pain.
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.