The Current Research Situation of Experimental Animal Models of Migraine
Abstract
Migraine is a genetically related recurrent headache syndrome appearing with neuro-psychological and gastrointestinal symptoms,implicating interaction between external triggers and internal pathophysiology.Its pathogenesis is still not completely clarified,animal models are established on the basis of trigeminovascular theory,cortical spreading depression theory and neurovascular theory.Here is to review the current migraine experimental animal models from the perspectives of modeling mechanism,characteristics,scope and validity,etc.
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