Activation of the trigeminal system in the animal models of migraine
Abstract
Cumulative impact factor of publications not directly related to the thesis: 39.098Total impact factor: 48.537 SummaryMigraine is one of the most common primary headaches, affecting up to 10% of the Hungarian population.The exact pathogenesis is still not fully understood, but the activation of the trigeminovascular system and neurogenic inflammation have a role in its pathomechanism.Serotonin is also strongly involved in the process, and its metabolite level is increased in the urine during migraine attacks.Serotonin transporter is the protein responsible for the reuptake of this transmitter from the synaptic cleft and extracellular space, and increased levels of its expression were found in the brainstem of migraineurs, showing that it might have a function in the pathomechanism of the disease.The cannabinoid system has a role in descending pain modulation, and its receptors are found in the trigeminal system as well.Anandamide is an endocannabinoid with antinociceptive properties, and it can decrease the activation and sensitization markers in the trigeminal system in the animal model of migraine.There are growing numbers of studies that suggest a connection between the endocannabinoid and the serotonin system, therefore, we aimed to (i) examine the serotonin transporter levels in the caudal trigeminal nucleus (TNC) of rats in the nitroglycerin model of migraine and (ii) study the effect of systemic anandamide treatment.Using immunohistochemistry and Western blot, we…
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