Effect of Different Proportion and Different Dosage Forms of Combination of Chuanxiong Rhizoma and Angelicae Dahuricae Radix on Migraine in Animal Models
Abstract
Objective:To observe the effects of different proportion and different dosage forms of the combination of Chuanxiong Rhizoma and Angelicae Dahuricae Radix on migraine in animal models.Method:One experimental migraine animal model was duplicated by abdominal injection of nitroglycerin(10 mg·kg-1) once,the other was duplicated by subcutaneous injection of reserpine(0.4 mg·kg-1) seven days.After model establishment,the animals were treated with the combination of Chuanxiong Rhizoma and Radix Angelicae Dahuricae,and the levels of 5-hydroxytryptamine(5-HT),5-hydroxyindole acedic acid(5-HIAA) and calatonin gene related peptide(CGRP) were determined.Result: Compared with model group,the combination of Chuanxiong Rhizoma and Angelicae Dahuricae Radix(3.5 g·kg-1·d-1)could raise the contents of 5-HT about 48.41%-73.18%,reduce the contents of CGRP about 38.02%-50.02%(P0.01)in migraine rats,and the combination(5 g·kg-1·d-1) could raise the contents of 5-HT about 36.60%-69.52% in migraine mouse(P0.05,P0.01).Conclusion: The combination of Chuanxiong Rhizoma and Angelicae Dahuricae Radix has the best effect when it was given by the form of powders.It could improve migraine symptoms by controlling single of neurotransmitter dopamine release and alleviating neurogenic inflammation.
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