Efficacy of aerobic training on resting-state brain wave, pain, sleep quality, and quality of life among university students with migraine symptoms: A randomized controlled trial
Abstract
Migraine is a paroxysmal neurovascular disorder characterised by cortical hyperexcitability and is often accompanied by sleep disturbances due to shared neural pathways. University students are particularly vulnerable, as stress and irregular sleep exacerbate symptoms and impair quality of life.
This study aims to assess the efficacy of aerobic training on resting-state alpha brain waves, migraine pain level, sleep quality, and quality of life, compared with electromyography biofeedback training and a placebo group among university students with migraine symptoms.
A pilot randomized controlled trial with pre- and post-test design using a parallel assignment intervention model and simple random sampling was conducted. University students meeting the criteria based on the Migraine Screen Questionnaire ≥ 4/5,
International Classification of Headache Disorders
, 3rd edition (ICHD-3) ≥ 5/7 were included. Participants with high scores on the Visual Aura Rating Scale, other primary headaches, and a history of secondary headaches associated with COVID-19 were excluded. Outcomes included resting-state EEG, migraine pain intensity level, Pittsburgh Sleep Quality Index, and Migraine Specific Quality of Life Scale, assessed at baseline and after 6 weeks of intervention.
A total of 87 university students with migraine symptoms completed the study. A significant time × group interaction effect was observed for resting-state alpha brain waves (
P
= .002), particularly in 10 Hz (
P
= .004)…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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