Refractory Mycoplasma pneumoniae with cytokine storm: a case report with an atypical presentation
Abstract
Mycoplasma pneumoniae is a significant cause of community-acquired pneumonia in children. Macrolide-resistant M. pneumoniae (MRMP) has been observed worldwide, with varying incidence rates. MRMP infections have a poor response to macrolide antibiotics, which further results in prolonged fever, extended antibiotic treatment, increased hospitalization, critical care unit admissions, and a significantly higher proportion of patients needing to receive glucocorticoids or second-line antibiotics. A 5-year-old girl presented with high-grade fever and lobar consolidation due to M. pneumoniae. She didn’t respond to macrolides. She developed features of cytokine storm with elevated ferritin, transaminitis etc. She was started on levofloxacin, given intravenous immunoglobulin and systemic corticosteroids, following which defervescence occurred. Early and rapid identification of resistant Mycoplasma infection is important. Appropriate antibiotic treatment, along with immunosuppressive therapy, is warranted for children with refractory M. pneumoniae pneumonia (MRMP).
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors
- Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.