Efficacy of cognitive behavioral therapy in chronic migraine and medication overuse headache: a prospective randomized trial
Abstract
Cognitive behavioral therapy (CBT) is recommended in the complex therapy of chronic migraine (CM) and medication overuse headache (MOH), but there are few randomized trials to evaluate its efficacy.Objective: to investigate the efficacy of an interdisciplinary program with CBT in the treatment of patients with CM and MOH.Material and methods. The study included 156 patients with CM and MOH (61 men and 95 women, mean age 34.1±8.9 years). All patients were clinically interviewed and tested with clinical and psychological methods. Patients were randomized into two groups: group 1 received standard treatment (pharmacotherapy – preventive and for migraine relief; lifestyle recommendations; detoxification therapy in MOB) and CBT, group 2 received only standard treatment. In all patients clinical and psychological parameters were assessed before treatment, and 3, 6, 12 and 18 months after the start of treatment.Results. After 3 months of treatment, a statistically significant improvement (p<0.05) was observed in group 1: reduction in headache frequency, frequency of taking painkillers (PC), scores on the Pain Catastrophizing Scale, the Spielberger–Khanin Personal and Situational Anxiety Scale, Centre for Epidemiologic Studies Depression Scale, Leeds Dependence Questionnaire (LDQ) and the Migraine Disability Assessment (MIDAS) Questionnaire (p<0.05). The improvement achieved was maintained after 6, 12 and 18 months of therapy. After 3 months of therapy, in group 2 a statistically…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 156 participants or records.
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