Unmet treatment needs in migraine: Results of the OVERCOME (US) study
Abstract
OBJECTIVE: To examine acute and preventive migraine prescription treatment needs among participants with active migraine and identify factors associated with needing treatment optimization.
BACKGROUND: A high unmet treatment need exists for individuals with migraine.
METHODS: ObserVational survey of the Epidemiology, tReatment and Care Of MigrainE (United States) is a prospective, multi-cohort, longitudinal, web-based survey in a demographically representative sample of US adults with active migraine in the preceding year. The current study is a pooled analysis of the baseline surveys of the 2018, 2019, and 2020 migraine cohorts. Criteria for determining need for migraine treatment initiation/modification were based on the American Headache Society 2021 consensus statement. For preventive treatment, need was defined based on the number of headache days per month and Migraine Disability Assessment Scale scores. For acute treatment, need was defined using the Migraine Treatment Optimization Questionnaire scores or based on the presence of two or more disability days per month. Participants were categorized into four groups based on their need for initiation/modification of acute or preventive treatment or both. The categories were "not a candidate (no need for treatment initiation/modification)," "acute need only," "preventive need only," or "preventive + acute needs." Interictal burden was measured using the Migraine Interictal Burden Scale-4.
RESULTS: Among 59,001…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 59,001 participants or records.
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