Migraine-associated symptoms change with improvement in youth with migraine: A cohort study
Abstract
AIM: To determine how migraine-associated symptoms change over time, and if they are predictive of outcome at first follow-up visit. Symptoms associated with headache-photophobia and phonophobia, nausea, and/or vomiting-are required criteria for the diagnosis of migraine. Individuals with migraine also report high rates of other symptoms (e.g. lightheadedness, difficulty thinking). We have developed cluster analysis of migraine-associated symptoms (CAMS), which is a composite representation of an expanded set of migraine-associated symptoms that is associated with headache burden. It is unknown if CAMS can change with treatment response or predict outcomes.
METHODS: We conducted a secondary analysis of prospectively collected clinician-guided patient questionnaire data from youth (6-17 years) with migraine who were seen at a specialized pediatric headache clinic. Data were collected at time of presentation and at the first follow-up within 30 to 90 days from the first visit. CAMS were implemented to assess associations between 11 migraine-associated symptoms. We determined if CAMS changed over time and as a function of treatment outcome, and if CAMS could be used to predict outcome at first follow-up.
RESULTS: Youth with migraine (n = 8008, 67.1% female, median 13 years old) were included in this study. CAMS revealed that the number of reported migraine-associated symptoms decreased at follow-up, particularly for those who improved. Resolution of nausea and vomiting were…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 8,008 participants or records.
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