Maternal migraine, vascular comorbidities, and prematurity: exploring overlooked associations in pregnancy
Abstract
Background: Prematurity remains a leading cause of neonatal morbidity and mortality, with lasting implications for neurodevelopment and lifelong health. This study aimed to investigate maternal and fetal factors associated with preterm birth within a cohort of pregnant women affected by migraine, with particular focus on vascular and metabolic comorbidities potentially contributing to adverse pregnancy outcomes.
Methods: We performed prospective cohort study. Pregnant women presenting in the first trimester (≤11 weeks gestation) with a history of migraine prior to conception and at least one migraine attack during the first trimester were enrolled. Participants underwent neurological evaluation to exclude secondary headache disorders and completed structured questionnaires on migraine frequency and intensity pregestation and during pregnancy. Participants were stratified by gestational age at delivery into preterm (<37 weeks) and term (≥37 weeks) groups. Maternal, fetal, and pregnancy-related variables assessed included maternal age, parity, maternal obesity, gestational weight gain, fetal growth restriction, delivery mode, pregnancy-induced hypertension, and gestational diabetes mellitus.
Results: A total of 400 women were included, of whom 65 delivered preterm. Statistically significant associations with preterm delivery were observed for pregnancy-induced hypertension (p p p = 0.021), excessive gestational weight gain (p p p p p = 0.015) and intensity (p = 0.020)…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 400 participants or records.
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