Adherence status and influencing factors of acute and preventive pharmacotherapy among migraine patients in China
Abstract
OBJECTIVE: To investigate the current adherence status and influencing factors for acute and preventive pharmacotherapy among migraine patients in China.
METHODS: Utilizing a prospective cohort design with retrospective identification, migraine patients first attending the Headache Clinic (Chinese PLA General Hospital, May-November 2024) were prospectively assessed for treatment adherence and influencing factors via structured telephone follow-ups.
RESULTS: Among 456 enrolled patients (75.9% female, 24.1% male), migraine subtypes included probable migraine (14.9%), migraine without aura (72.6%), migraine with aura (4.2%), and chronic migraine (8.3%). Good adherence rates were 30.5% for acute and 53.3% for preventive pharmacotherapy. Key non-adherence behaviors for acute medication: Abstinence from medication during attacks (63.1%) and administration after pain progression to moderate/severe intensity (35.0%). Primary reasons: mild headache deemed non-requiring medication (43.3%) and fear of potential adverse effects (36.0%). Key non-adherence behaviors for preventive medication: incomplete treatment course duration (76.4%), failure to obtain prescribed medications (15.3%), and non-adherence to prescribed medication schedule (11.1%). Primary reasons given for nonadherence to preventive medication included perceived prescription inappropriateness (43.1%) and adverse effects that occurred (19.4%). Multivariate regression analysis revealed that adherence to acute pharmacotherapy…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 456 participants or records.
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