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Comparison of the Efficacy of Ultrasound-Guided Repeated Greater Occipital Nerve Blocks and Greater Occipital Nerve Pulsed Radiofrequency in Migraine Treatment

Dadali S, Babaoglu G, Sabuncu U, Akcaboy EY

Pain physician, 2025

68 participants

Abstract

BACKGROUND: Greater occipital nerve (GON) blocks and pulsed radiofrequency (PRF) are commonly used in migraine management.

OBJECTIVES: This study compares the clinical outcomes of migraine patients who underwent repeated GON blocks (GONBs) and pulsed radiofrequency of the greater occipital nerve (GONPRF), both of which were performed using a proximal technique with ultrasound (US)-guidance.

STUDY DESIGN: Single-center, prospective, comparative, observational cohort study.

SETTING: Tertiary referral center.

METHODS: Patients who were diagnosed with migraines based on the criteria from the International Classification of Headache Disorders III, experienced migraine attacks at least once a week or 5 times per month, did not respond to preventive migraine medications, and had a positive response to diagnostic GONB treatment (2-4 mL of 0.25% bupivacaine) were included in the study.The first group (the GONBs group) consisted of patients who could visit the clinic regularly. In this group, a GONB was administered at the C2 level using a proximal technique under US-guidance once a week for 4 weeks. The second group (the GONPRF group) included patients who, for various reasons, had only a limited ability to attend weekly treatments. In this group, GONPRF was performed at the C2 level using a proximal technique under US-guidance.For both groups, the following outcomes were evaluated at the first, second, and third months after treatment: headache attack duration, monthly frequency of…

How strong is the evidence?

Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 68 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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