Evaluating associations of migraine-related vertigo
Abstract
OBJECTIVE: We set out to examine detailed phenotypic data from our clinic for associations of vertigo in chronic migraine.
BACKGROUND: Vertigo is a non-canonical, common symptom of migraine. Little is known about its associations with other symptoms within the migraine phenotype. There is significant methodological heterogeneity and therefore inadequate overall evidence about the potential differences in efficacy of any migraine treatments in patients with problematic vertigo associated with migraine, compared to those without vertigo. Enhancing understanding of migraine-related vertigo could help guide treatment and inform on mechanisms of vestibular migraine, a poorly understood diagnostic entity.
METHODS: Chronic migraine extended phenotypes of patients seen within the adult headache service at King's College Hospital Tertiary Headache Service between January 2014 and December 2021 (n = 589) were extracted from the first documented clinic consultation letter retrospectively. For those with information about vertigo (n = 562), potential associations of interest for the presence of vertigo (gender, allodynia, aura, photophobia, phonophobia and osmophobia, baseline headache frequency, number of premonitory symptoms, presence of cranial autonomic symptoms, and age) were analyzed using a regression model (IBM SPSS v 29). Missing data were excluded (final n = 435).
RESULTS: The total sample size for analysis in the regression model was n = 435, after excluding missing data (n =…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 589 participants or records.
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