Association of Migraine with Increased Risk of Central Serous Chorioretinopathy: A retrospective Cohort Study
Abstract
BACKGROUND
To evaluate whether migraine is associated with an increased risk of developing central serous chorioretinopathy (CSCR) using a large real-world electronic medical record dataset.
DESIGN
Retrospective cohort study.
PARTICIPANTS AND CONTROLS
Adults aged 18-40 years with a diagnosis of migraine were identified from the TriNetX Global Collaborative Network and compared to individuals without migraine or other headache syndromes who underwent routine medical examinations. Patients with a history of CSCR or corticosteroid use within one month before or after the index migraine diagnosis were excluded. All patients had at least one year of follow-up data after the index date.
METHODS
Propensity score matching (PSM) was performed in a 1:1 ratio to balance baseline demographic and clinical characteristics. Time-to-event analysis was conducted using Cox proportional hazards models and log-rank tests. Subgroup and sensitivity analyses assessed the robustness of the association across sex, migraine subtypes (with and without aura), age range, follow-up duration, corticosteroid exposure, and an alternative multivariable Cox regression in the full cohorts. Additional analyses evaluated the effect of migraine-related medications on CSCR risk.
MAIN OUTCOME MEASURES
Incident CSCR within five years of the index date. The E-value was calculated to evaluate robustness against unmeasured confounding.
RESULTS
After matching, 413,663 patients with balanced baseline characteristics…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 413,663 participants or records.
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