Comparative effectiveness of weekly versus biweekly combined greater and supraorbital nerve blocks in chronic migraine: A retrospective observational cohort study
Abstract
BACKGROUND/OBJECTIVE
Greater occipital nerve (GON) and supraorbital nerve (SON) blocks are effective interventional options for chronic migraine treatment; however, the optimal frequency of injections remains undefined. This study aims to compare the short-term efficacy of weekly and biweekly GON and SON blocks in patients with chronic migraine (CM). The focus will be on pain intensity, monthly headache days (MHD), analgesic consumption and migraine-related disability.
MATERIALS AND METHODS
This single-center, retrospective cohort study included adults meeting The International Classification of Headache Disorders, 3rd edition (ICHD-3) criteria for chronic migraine who received either weekly (n = 45) or biweekly (n = 52) standardized bilateral GON and SON blocks. The primary outcome was the change in MHD; secondary outcomes were The Visual Analogue Scale (VAS) pain scores, monthly analgesic consumption, The Migraine Disability Assessment (MIDAS) scores, responder rates, and adverse events. Within-group changes were analyzed using the Wilcoxon signed-rank test with Bonferroni correction, and between-group comparisons with the Mann-Whitney U or chi-square test. Effect sizes were calculated using Cohen's d.
RESULTS
Baseline characteristics were comparable between groups (all p > 0.05). Both protocols produced significant improvements in VAS, MHD, analgesic use, and MIDAS scores from baseline to 3 months (all p 0.17), and between-group effect sizes were small (|d| < 0.15).…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 52 participants or records.
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