Association Between Obesity and the Risk of Migraine: A Nationwide Cohort Study in South Korea
Abstract
BACKGROUND AND OBJECTIVES
Although obesity is recognized as a risk factor of migraine chronification, its longitudinal impact on migraine onset remains unclear. The aim of this study was to investigate the association between obesity and the risk of developing migraine in a longitudinal setting.
METHODS
We conducted a population-based prospective cohort study using data from the Korean National Health Insurance Service. Individuals aged 20-39 years who underwent health examinations between 2009 and 2012 were enrolled, excluding those with a history of migraine, missing data, or a migraine diagnosis within the first year. Participants were followed to the end of 2018. Body mass index (BMI) was categorized into 5 groups and waist circumference (WC) into 6 levels. Outcome was the first migraine claim (International Classification of Diseases, Tenth Revision code G43). We evaluated the associations of BMI and WC with the risk of migraine using multivariable Cox proportional hazard regression models. Interaction analyses were conducted based on demographic and lifestyle factors.
RESULTS
Among 6,106,560 individuals included (mean age: 30.6 ± 4.98 years; 39% female), the risk of migraine increased with increasing BMI (adjusted hazard ratio [aHR] 1.001 [95% CI 0.991-1.010], 1.047 [95% CI 1.040-1.055], 1.087 [95% CI 1.079-1.094], and 1.121 [95% CI 1.106-1.136] for underweight, overweight, stage 1 obesity, and stage 2 obesity, respectively, compared with normal BMI) and WC (aHR 0.913…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 6,106,560 participants or records.
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