The Role of Inflammatory Markers in Predicting the Effectiveness of Greater Occipital Nerve Block in Chronic Migraine: Retrospective Cohort Study
Abstract
ABS TRACT Objective: This study was aimed to evaluate whether systemic inflammatory markers-specifically the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI)-could serve as reliable predictors in determining the clinical efficacy of greater occipital nerve (GON) block treatment among patients suffering from chronic migraine. Material and Meth-ods: This retrospective cohort study included 48 adult patients who had been diagnosed with and who underwent GON block therapy between 2020 and 2025. Each patient received a standardized protocol consisting of seven GON block interventions. The therapeutic response was defined as a reduction of ≥ 50% in the number of monthly headache days compared to baseline. Demographics and inflammatory indices were derived from the complete blood count (NLR, SII, SIRI, and AISI) were collected and analyzed. The cohort was then divided into responders and non-responders based on clinical outcome. Results: A favorable treatment response was observed in 33 (68.7%). No statistically significant differences were found in baseline demographic variables, between the responder and non-responder groups. Similarly, none of the inflammatory markers-NLR, SII, SIRI, and AISI-showed significant differences between the 2 groups (p>0.05). Conclusion: The findings of this study suggest that systemic inflammatory markers such as NLR, SII,…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 48 participants or records.
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